RESUMEN
Background: Family of colony-stimulating factors [CSF] have an essential role on early cross talk between embryo and uterine endometrium
Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF [G-CSF] injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures
Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 Mug [0.5 ml] recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer
Results: There was not statistically significant differences in abortion rate in G-CSF and control group [p=0.09]. G-CSF treated group showed higher clinical pregnancy rate in comparison with control group [56.2% vs. 40.0%] but it was not statistically significant [p=0.09]. Although live birth rate in G-CSF group was higher than control group [53.1% vs. 35.0%] but there wasn't statistically significant difference in the overall live birth rate between the two groups [p=0.10]. G-CSF group had a twin pregnancies while in control group there was no twin pregnancy
Conclusion: Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF